Megestrol acetate for treatment of anorexia‐cachexia syndrome
Anorexia‐cachexia syndrome (ACS) is a common clinical problem characterised by loss of appetite and weight loss. It is common in patients who suffer from advanced cancer, AIDS and some other conditions. At present, there is no cure for ACS.
Megestrol acetate (MA) is classified as a female hormone and is taken by mouth. It is currently used to improve appetite and to increase weight in ACS.
This updated review shows that:
MA improves appetite and has a small effect on weight gain;
MA does not improve quality of life;
side effects are more frequent in patients treated with MA.
This review shows that MA is associated with an increased risk of blood clots (which may result in swelling, pain or redness of one extremity and not the other, sudden difficulty in breathing, severe headache or vision changes), fluid retention (resulting in swelling of the feet or hands) and death.
In patients who take MA, approximately one in four will have an increase in their appetite, one in 12 will have an increase in their weight and one in 23 will die.
Limited data are available regarding the safety of using MA, especially in the long term.
Abstract
Background: This is an updated version of a previously published review in The Cochrane Library (2005, Issue 2) on 'Megestrol acetate for the treatment of anorexia‐cachexia syndrome'. Megestrol acetate (MA) is currently used to improve appetite and to increase weight in cancer‐associated anorexia. In 1993, MA was approved by the US Food and Drug Administration for the treatment of anorexia, cachexia or unexplained weight loss in patients with AIDS. The mechanism by which MA increases appetite is unknown and its effectiveness for anorexia and cachexia in neoplastic and AIDS (acquired immunodeficiency syndrome) patients is under investigation.
Objectives: To evaluate the efficacy, effectiveness and safety of MA in palliating anorexia‐cachexia syndrome in patients with cancer, AIDS and other underlying pathologies.
Search methods: We sought studies through an extensive search of electronic databases, journals, reference lists, contact with investigators and other search strategies outlined in the methods. The most recent search for this update was carried out in May 2012.
Selection criteria: Studies were included in the review if they assessed MA compared to placebo or other drug treatments in randomised controlled trials of patients with a clinical diagnosis of anorexia‐cachexia syndrome related to cancer, AIDS or any other underlying pathology.
Data collection and analysis: Two independent review authors conducted data extraction and evaluated methodological quality. We performed quantitative analyses using appetite and quality of life as a dichotomous variable, and analysed weight gain as continuous and dichotomous variables.
Main results: We included 35 trials in this update, the same number but not the same trials as in the previous version of the review. The trials comprised 3963 patients for effectiveness and 3180 for safety. Sixteen trials compared MA at different doses with placebo, seven trials compared different doses of MA with other drug treatments and 10 trials compared different doses of MA. Meta‐analysis showed a benefit of MA compared with placebo, particularly with regard to appetite improvement and weight gain in cancer, AIDS and other underlying conditions, and lack of benefit in the same patients when MA was compared to other drugs. There was insufficient information to define the optimal dose of MA, but higher doses were more related to weight improvement than lower doses. Quality of life improvement in patients was seen only when comparing MA versus placebo but not other drugs in both subcategories: cancer and AIDS. Oedema, thromboembolic phenomena and deaths were more frequent in the patients treated with MA. More than 40 side effects were studied.
Authors' conclusions: This review shows that MA improves appetite and is associated with slight weight gain in cancer, AIDS and in patients with other underlying pathology. Despite the fact that these patients are receiving palliative care they should be informed of the risks involved in taking MA.
Editorial Group: Cochrane Pain, Palliative and Supportive Care Group.
Publication status: New search for studies and content updated (conclusions changed).
Citation: Ruiz Garcia V, López‐Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort‐Marti S. Megestrol acetate for treatment of anorexia‐cachexia syndrome. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD004310. DOI: 10.1002/14651858.CD004310.pub3.
Source: https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0012691/
Saturday, June 13, 2026
Kamagra: Side Effects, Drug Interactions, And Precautions
Every medication carries the potential for side effects, and Kamagra (sildenafil) is no exception. Understanding what side effects are possible, which are common versus rare, and what warning signs warrant medical attention allows patients to use the medication safely and confidently. Most people who take Kamagra as directed tolerate it without major problems, but individual responses vary. Allergy treatment has advanced considerably over the past several decades. Early antihistamines were effective but caused significant drowsiness. Modern second-generation antihistamines provide comparable or superior symptom control without the sedating side effects that limited their predecessors. Other treatment modalities include nasal corticosteroid sprays, which reduce airway inflammation, and allergen immunotherapy, which gradually desensitizes the immune system through controlled exposure to specific allergens over time. The most frequently reported side effects of sildenafil are typically mild and often resolve within days to weeks as the body adjusts. Serious side effects occur less frequently but are documented in prescribing information and patient safety guides. Complete side effect information and precautions are listed at https://mednewwsstoday.com/sexual-health/kamagra-sildenafil/, which serves as a reliable reference for anyone beginning therapy with Kamagra or monitoring an ongoing treatment. Drug interactions are an important safety consideration for any medication. Kamagra may interact with other prescription drugs, over-the-counter medications, supplements, or certain foods, affecting how it is metabolized or how effective it is. A pharmacist or doctor can review a patient's full medication list to identify any clinically significant interactions before starting Kamagra. Patients should also avoid making changes to their medication regimen without first consulting a healthcare professional. More information on medications used in sexual health and how they compare in terms of safety and efficacy is available through the resource at sexual health. Staying informed helps patients participate actively in decisions about their care.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.